| NCAAF | 11/04 16:00 | 1 | Juniata Eagles v Keystone Giants | W | 35-42 | |
| NCAAF | 10/28 16:00 | 1 | Keystone Giants v Catholic Cardinals | L | 14-26 | |
| NCAAF | 10/21 17:00 | 1 | Keystone Giants v Lycoming Warriors | L | 7-34 | |
| NCAAF | 10/14 16:00 | 1 | Wilkes Colonels v Keystone Giants | L | 42-7 | |
| NCAAF | 10/07 17:00 | 1 | Keystone Giants v Susquehanna Crusaders | L | 0-69 | |
| NCAAF | 09/30 17:00 | 1 | Moravian Greyhounds v Keystone Giants | L | 58-34 | |
| NCAAF | 09/23 22:00 | 1 | Hobart Statesmen v Keystone Giants | L | 43-10 | |
| NCAAF | 09/16 17:00 | 1 | Keystone Giants v St John Fisher Cardinals | L | 20-35 | |
| NCAAF | 09/09 17:00 | 1 | Hartwick Hawks v Keystone Giants | L | 31-21 | |
| NCAAF | 09/02 16:00 | 1 | Keystone Giants v Gallaudet Bison | W | 27-6 | |
| NCAAF | 11/12 17:00 | 1 | Dean Bulldogs v Keystone Giants | W | 44-45 | |
| NCAAF | 11/05 17:00 | 1 | Keystone Giants v Suny Maritime Privateers | W | 21-20 | |
| NCAAF | 10/22 16:00 | 1 | Keystone Giants v Castleton Spartans | L | 20-35 | |
| NCAAF | 10/15 16:00 | 1 |
Anna Maria Amcats
v
Keystone Giants
|
W | 39-41 | |
| NCAAF | 10/08 17:00 | 1 |
Alfred State Pioneers
v
Keystone Giants
|
L | 42-33 | |
| NCAAF | 10/01 16:00 | 1 | Keystone Giants v Gallaudet Bison | L | 44-52 | |
| NCAAF | 09/24 17:30 | 1 | Keystone Giants v Hobart Statesmen | L | 6-65 | |
| NCAAF | 09/17 17:00 | 1 | William Paterson Pioneers v Keystone Giants | L | 27-20 | |
| NCAAF | 09/10 17:00 | 1 | Misericordia Cougars v Keystone Giants | L | 38-20 | |
| NCAAF | 09/03 17:00 | 1 | Keystone Giants v Wilkes Colonels | L | 21-48 | |
| NCAAF | 11/06 17:00 | 1 | Suny Maritime Privateers v Keystone Giants | L | 24-21 | |
| NCAAF | 10/30 18:00 | 1 |
Keystone Giants
v
Alfred State Pioneers
|
L | 7-38 | |
| NCAAF | 10/23 16:00 | 1 | Castleton Spartans v Keystone Giants | L | 41-0 | |
| NCAAF | 10/16 16:00 | 1 | Keystone Giants v Dean Bulldogs | L | 36-39 | |
| NCAAF | 10/09 16:00 | 1 | Gallaudet Bison v Keystone Giants | L | 34-14 | |
| NCAAF | 10/02 16:00 | 1 |
Keystone Giants
v
Anna Maria Amcats
|
L | 35-55 | |
| NCAAF | 09/25 22:00 | 1 | Hobart Statesmen v Keystone Giants | L | 58-14 | |
| NCAAF | 09/18 17:00 | 1 | Keystone Giants v William Paterson Pioneers | L | 14-42 | |
| NCAAF | 09/11 16:00 | 1 | Keystone Giants v Misericordia Cougars | L | 7-28 | |
| NCAAF | 09/04 17:00 | 1 | Wilkes Colonels v Keystone Giants | L | 46-7 |