| NCAAF | 10/02 17:00 | 1 | Depauw Tigers v Hiram Terriers | W | 57-7 | |
| NCAAF | 09/25 18:00 | 1 | Wooster Scots v Depauw Tigers | W | 30-34 | |
| NCAAF | 09/18 17:00 | 1 | Depauw Tigers v Kenyon Lords | W | 44-0 | |
| NCAAF | 09/11 22:00 | 1 | Butler v Depauw Tigers | L | 49-24 | |
| NCAAF | 11/16 18:00 | 1 | Depauw Tigers v Wabash Little Giants | W | 17-13 | |
| NCAAF | 11/09 18:00 | 1 | Depauw Tigers v Oberlin Yeomen | W | 34-0 | |
| NCAAF | 11/02 22:00 | 1 | Denison Big Red v Depauw Tigers | L | 42-7 | |
| NCAAF | 10/26 17:00 | 1 |
Depauw Tigers
v
Allegheny Gators
|
W | 8-6 | |
| NCAAF | 10/19 18:00 | 1 | Ohio Wesleyan Battling Bishops v Depauw Tigers | L | 28-13 | |
| NCAAF | 10/12 17:00 | 1 | Hiram Terriers v Depauw Tigers | W | 7-21 | |
| NCAAF | 10/05 17:00 | 1 | Depauw Tigers v Wooster Scots | W | 31-26 | |
| NCAAF | 09/28 17:00 | 1 | Depauw Tigers v Wittenberg Tigers | L | 10-17 | |
| NCAAF | 09/21 16:00 | 1 | Kenyon Lords v Depauw Tigers | W | 7-21 | |
| NCAAF | 09/14 18:00 | 1 | Central Dutch v Depauw Tigers | L | 45-19 | |
| NCAAF | 11/10 18:07 | 1 | Wabash Little Giants v Depauw Tigers | L | 24-17 | |
| NCAAF | 11/03 17:00 | 1 | Depauw Tigers v Kenyon Lords | W | 38-6 | |
| NCAAF | 10/27 17:00 | 1 |
Allegheny Gators
v
Depauw Tigers
|
L | 20-19 | |
| NCAAF | 10/20 17:00 | 1 | Wittenberg Tigers v Depauw Tigers | L | 38-23 | |
| NCAAF | 10/13 17:00 | 1 | Depauw Tigers v Denison Big Red | L | 12-20 | |
| NCAAF | 10/06 17:00 | 1 | Oberlin Yeomen v Depauw Tigers | W | 26-28 | |
| NCAAF | 09/29 17:00 | 1 | Depauw Tigers v Ohio Wesleyan Battling Bishops | W | 38-17 | |
| NCAAF | 09/22 17:00 | 1 | Wooster Scots v Depauw Tigers | L | 24-21 | |
| NCAAF | 09/15 17:00 | 1 | Depauw Tigers v Hiram Terriers | W | 45-7 | |
| NCAAF | 09/08 17:00 | 1 | Depauw Tigers v Central Dutch | L | 10-16 |