| WNCAAB | 11/18 22:00 | - | [195] Western Carolina - naised v USC Upstate - naised [272] | L | 58-48 | |
| WNCAAB | 11/15 00:00 | - | [226] USC Upstate - naised v Virginia Tech - naised [36] | L | 24-79 | |
| WNCAAB | 11/11 00:00 | - | [115] USC Upstate - naised v West Virginia - naised [205] | L | 31-81 | |
| WNCAAB | 11/07 22:00 | - | Southern Wesleyan - naised v USC Upstate - naised | W | 51-69 | |
| WNCAAB | 03/04 01:00 | 3 | [1024] UNC Asheville - naised v USC Upstate - naised [38] | L | 62-57 | |
| WNCAAB | 02/26 18:00 | - | [41] USC Upstate - naised v North Carolina A&T - naised [177] | W | 74-63 | |
| WNCAAB | 02/23 23:00 | - | [123] Longwood - naised v USC Upstate - naised [28] | L | 71-66 | |
| WNCAAB | 02/19 19:00 | - | USC Upstate - naised v UNC Asheville - naised | W | 68-57 | |
| WNCAAB | 02/16 23:00 | - | [40] USC Upstate - naised v Presbyterian - naised [982] | W | 80-67 | |
| WNCAAB | 02/15 23:00 | - | [973] Presbyterian - naised v USC Upstate - naised [45] | W | 66-68 | |
| WNCAAB | 02/12 19:00 | - | [33] USC Upstate - naised v High Point - naised [181] | L | 59-75 | |
| WNCAAB | 02/09 23:00 | - | [1047] Winthrop - naised v USC Upstate - naised [34] | W | 47-59 | |
| WNCAAB | 02/09 00:00 | - | [48] USC Upstate - naised v Winthrop - naised [1041] | W | 73-43 | |
| WNCAAB | 02/05 20:00 | - | USC Upstate - naised v Hampton - naised | W | 60-58 | |
| WNCAAB | 02/03 23:00 | - | [893] Hampton - naised v USC Upstate - naised [65] | W | 59-65 | |
| WNCAAB | 02/02 00:00 | - | Radford - naised v USC Upstate - naised | W | 55-66 | |
| WNCAAB | 01/29 21:00 | - | [36] Campbell - naised v USC Upstate - naised [76] | W | 62-81 | |
| WNCAAB | 01/25 23:00 | - | [970] Gardner Webb - naised v USC Upstate - naised [84] | W | 68-71 | |
| WNCAAB | 01/22 19:00 | - | [70] USC Upstate - naised v Charleston Southern - naised [1066] | L | 53-55 | |
| WNCAAB | 01/19 20:00 | - | USC Upstate - naised v Longwood - naised | W | 76-69 | |
| WNCAAB | 01/15 21:00 | - | [1024] North Carolina A&T - naised v USC Upstate - naised [95] | W | 64-67 | |
| WNCAAB | 01/12 22:00 | - | [1013] High Point - naised v USC Upstate - naised [75] | L | 83-73 | |
| WNCAAB | 01/01 21:00 | - | [191] UNC Asheville - naised v USC Upstate - naised [85] | W | 53-66 | |
| WNCAAB | 12/19 19:00 | - | [50] USC Upstate - naised v Kentucky - naised [118] | L | 44-67 | |
| WNCAAB | 12/18 19:00 | - | Morehead State - naised v USC Upstate - naised | W | 52-66 | |
| WNCAAB | 12/16 23:00 | - | USC Upstate - naised v Bob Jones Bruins Women | W | 86-36 | |
| WNCAAB | 12/13 23:00 | - | [89] Jacksonville - naised v USC Upstate - naised [115] | W | 53-70 | |
| WNCAAB | 12/04 19:00 | - | [819] UNC Greensboro - naised v USC Upstate - naised [113] | W | 46-57 | |
| WNCAAB | 12/02 00:30 | - | [151] USC Upstate - naised v Western Carolina - naised [138] | W | 58-51 | |
| WNCAAB | 11/28 19:00 | - | USC Upstate - naised v Mars Hill Women | W | 102-40 |