[14] Louisville 16-31 Clemson [1] 2022-11-12 20:30
Stadium: Memorial Stadium Round: 1
Home Manager: Dabo Swinney Away Manager: Scott Satterfield
Head to Head
| NCAAF | 2021/11/06 23:30 | Clemson v Louisville | L | 30-24 |
| NCAAF | 2019/10/19 16:00 | Clemson v Louisville | L | 45-10 |
| NCAAF | 2018/11/03 16:00 | Louisville v Clemson | L | 16-77 |
| NCAAF | 2017/09/17 00:00 | Clemson v Louisville | L | 47-21 |
| NCAAF | 2016/10/02 00:00 | Louisville v Clemson | L | 36-42 |
| NCAAF | 2015/09/17 23:30 | Louisville v Clemson | L | 17-20 |
| NCAAF | 2014/10/11 19:30 | Clemson v Louisville | L | 23-17 |