[13] SJ Sharks 3-6 BUF Sabres [26] 2022-12-05 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: David Quinn
Head to Head
| NHL | 2022/01/07 00:00 | SJ Sharks v BUF Sabres | W | 3-2 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | W | 3-5 |
| NHL | 2019/10/22 23:00 | SJ Sharks v BUF Sabres | L | 3-4 |
| NHL | 2019/10/20 02:30 | BUF Sabres v SJ Sharks | L | 4-3 |
| NHL | 2018/11/28 00:00 | SJ Sharks v BUF Sabres | L | 2-3 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | W | 1-5 |
| NHL | 2017/10/28 17:00 | SJ Sharks v BUF Sabres | W | 3-2 |
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | W | 2-3 |
| NHL | 2017/03/15 02:30 | BUF Sabres v SJ Sharks | W | 1-4 |
| NHL | 2017/02/08 00:00 | SJ Sharks v BUF Sabres | L | 4-5 |