[5] TB Lightning 1-5 BUF Sabres [2] 2021-10-25 23:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Jon Cooper
Head to Head
| NHL | 2020/01/01 00:00 | TB Lightning v BUF Sabres | W | 6-4 |
| NHL | 2019/11/26 00:00 | BUF Sabres v TB Lightning | W | 2-5 |
| NHL | 2019/11/09 18:00 | BUF Sabres v TB Lightning | W | 3-5 |
| NHL | 2019/11/08 19:00 | TB Lightning v BUF Sabres | W | 3-2 |
| NHL | 2019/02/22 00:30 | BUF Sabres v TB Lightning | W | 1-2 |
| NHL | 2019/01/13 00:00 | TB Lightning v BUF Sabres | W | 5-3 |
| NHL | 2018/11/30 00:30 | BUF Sabres v TB Lightning | W | 4-5 |
| NHL | 2018/11/14 00:30 | TB Lightning v BUF Sabres | L | 1-2 |
| NHL | 2018/04/06 23:30 | BUF Sabres v TB Lightning | W | 5-7 |
| NHL | 2018/03/01 00:00 | BUF Sabres v TB Lightning | L | 2-1 |
| NHL | 2018/02/14 00:00 | TB Lightning v BUF Sabres | L | 3-5 |
| NHL | 2017/11/29 00:00 | TB Lightning v BUF Sabres | W | 2-0 |
| NHL | 2017/04/09 21:00 | BUF Sabres v TB Lightning | W | 2-4 |
| NHL | 2017/03/05 00:00 | TB Lightning v BUF Sabres | W | 2-1 |
| NHL | 2017/01/13 00:30 | BUF Sabres v TB Lightning | W | 2-4 |
| NHL | 2016/11/18 00:00 | TB Lightning v BUF Sabres | W | 4-1 |