Stadium: Seaverns Field at Harold Alfond Stadium Round: 1
| NCAAF | 2022/10/08 17:00 | Wesleyan Cardinals v Colby Mules | L | 31-14 |
| NCAAF | 2021/09/18 17:00 | Colby Mules v Wesleyan Cardinals | L | 5-21 |
| NCAAF | 2019/09/14 17:00 | Wesleyan Cardinals v Colby Mules | L | 30-10 |
| NCAAF | 2018/10/06 17:00 | Colby Mules v Wesleyan Cardinals | L | 20-28 |
| NCAAF | 2023/09/30 22:00 | Bates Bobcats v Colby Mules | W | 24-30 |
| NCAAF | 2023/09/23 17:00 | Colby Mules v Trinity Bantams | L | 7-48 |
| NCAAF | 2023/09/16 17:00 | Williams Ephs v Colby Mules | L | 25-22 |
| NCAAF | 2022/11/12 22:30 | Bowdoin Polar Bears v Colby Mules | L | 21-14 |
| NCAAF | 2022/11/05 17:00 | Colby Mules v Tufts Jumbos | L | 7-35 |
| NCAAF | 2022/10/29 17:00 | Middlebury Panthers v Colby Mules | L | 20-17 |
| NCAAF | 2022/10/22 16:00 | Hamilton Continentals v Colby Mules | W | 12-18 |
| NCAAF | 2022/10/15 17:00 | Colby Mules v Amherst Mammoths | W | 17-12 |
| NCAAF | 2023/09/30 17:00 | Wesleyan Cardinals v Hamilton Continentals | W | 35-14 |
| NCAAF | 2023/09/23 17:00 | Wesleyan Cardinals v Middlebury Panthers | W | 24-21 |
| NCAAF | 2023/09/15 23:00 | Bates Bobcats v Wesleyan Cardinals | W | 17-28 |
| NCAAF | 2022/11/12 17:00 | Trinity Bantams v Wesleyan Cardinals | L | 31-14 |
| NCAAF | 2022/11/05 17:00 | Wesleyan Cardinals v Williams Ephs | W | 35-21 |
| NCAAF | 2022/10/29 17:00 | Amherst Mammoths v Wesleyan Cardinals | W | 7-13 |
| NCAAF | 2022/10/22 17:00 | Bowdoin Polar Bears v Wesleyan Cardinals | L | 28-26 |
| NCAAF | 2022/10/15 22:00 | Wesleyan Cardinals v Tufts Jumbos | W | 26-22 |