Stadium: Carl Smith Stadium Round: 1
| NCAAF | 2022/10/08 17:00 | Emory And Henry Wasps v Virginia Wise Highland Cavaliers | L | 34-14 |
| NCAAF | 2023/09/30 18:00 | Lenoir Rhyne Bears v Virginia Wise Highland Cavaliers | L | 56-3 |
| NCAAF | 2023/09/23 18:00 | Virginia Wise Highland Cavaliers v Limestone Saints | L | 17-38 |
| NCAAF | 2023/09/16 20:00 | Barton Bulldogs v Virginia Wise Highland Cavaliers | L | 28-24 |
| NCAAF | 2023/09/09 16:00 | Thomas More Saints v Virginia Wise Highland Cavaliers | L | 37-0 |
| NCAAF | 2023/09/02 23:00 | Virginia Wise Highland Cavaliers v Union College Bulldogs | W | 48-0 |
| NCAAF | 2022/11/12 18:30 | Wingate Bulldogs v Virginia Wise Highland Cavaliers | L | 45-7 |
| NCAAF | 2022/11/05 19:00 | Carson–Newman Eagles v Virginia Wise Highland Cavaliers | L | 38-22 |
| NCAAF | 2022/10/29 16:00 | Virginia Wise Highland Cavaliers v Mars Hill Lions | L | 16-20 |
| NCAAF | 2023/09/30 22:00 | Catawba Indians v Emory And Henry Wasps | L | 30-13 |
| NCAAF | 2023/09/23 17:00 | Emory And Henry Wasps v Wingate Bulldogs | L | 10-31 |
| NCAAF | 2023/09/16 22:00 | Newberry Wolves v Emory And Henry Wasps | L | 25-23 |
| NCAAF | 2023/09/09 17:00 | Bluefield State v Emory And Henry Wasps | W | 14-37 |
| NCAAF | 2023/09/02 17:00 | Concord University Mountain Lions v Emory And Henry Wasps | W | 10-56 |
| NCAAF | 2022/11/12 17:00 | Limestone Saints v Emory And Henry Wasps | L | 45-27 |
| NCAAF | 2022/11/05 20:00 | Erskine Flying Fleet v Emory And Henry Wasps | W | 0-32 |
| NCAAF | 2022/10/29 17:00 | Emory And Henry Wasps v Carson–Newman Eagles | L | 7-21 |