Stadium: Braly Municipal Stadium Round: 1
Home Manager: Chris Willis Away Manager:
| NCAAF | 2022/09/01 22:00 | North Alabama v Indiana State | L | 14-17 |
| NCAAF | 2021/11/20 18:00 | North Alabama v Hampton | W | 35-27 |
| NCAAF | 2021/11/13 20:00 | Kennesaw State v North Alabama | L | 28-24 |
| NCAAF | 2021/11/06 17:00 | North Alabama v Monmouth | L | 33-45 |
| NCAAF | 2021/10/23 19:00 | Charleston Southern v North Alabama | W | 22-45 |
| NCAAF | 2021/10/16 23:00 | Robert Morris v North Alabama | W | 31-42 |
| NCAAF | 2021/10/09 17:00 | North Alabama v North Carolina A&T | L | 34-38 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | L | 48-31 |
| NCAAF | 2022/09/01 23:00 | Virginia Wise Highland Cavaliers v Ferrum Panthers | W | 41-9 |
| NCAAF | 2021/11/13 17:00 | Virginia Wise Highland Cavaliers v Barton Bulldogs | L | 24-36 |
| NCAAF | 2021/11/06 17:00 | Catawba Indians v Virginia Wise Highland Cavaliers | W | 7-30 |
| NCAAF | 2021/10/30 20:00 | Limestone Saints v Virginia Wise Highland Cavaliers | W | 24-28 |
| NCAAF | 2021/10/23 16:00 | Virginia Wise Highland Cavaliers v Wingate Bulldogs | L | 21-48 |
| NCAAF | 2021/10/16 17:30 | Tusculum Pioneers v Virginia Wise Highland Cavaliers | L | 37-21 |
| NCAAF | 2021/10/09 16:00 | Virginia Wise Highland Cavaliers v Newberry Wolves | L | 14-37 |
| NCAAF | 2021/10/02 18:00 | Virginia Wise Highland Cavaliers v Lenoir Rhyne Bears | W | 35-28 |