[6] BUF Sabres 3-4 BOS Bruins [5] 2022-01-01 18:00
Stadium: TD Garden
Home Manager: Bruce Cassidy Away Manager: Don Granato
Head to Head
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/10/22 23:00 | BOS Bruins v BUF Sabres | L | 4-1 |
| NHL | 2021/05/01 17:00 | BUF Sabres v BOS Bruins | L | 2-6 |
| NHL | 2021/04/29 23:00 | BUF Sabres v BOS Bruins | L | 2-5 |
| NHL | 2021/04/23 23:00 | BOS Bruins v BUF Sabres | W | 4-6 |
| NHL | 2021/04/22 23:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/04/20 22:30 | BOS Bruins v BUF Sabres | L | 2-0 |
| NHL | 2021/04/13 23:00 | BUF Sabres v BOS Bruins | L | 2-3 |
Home History
| NHL | 2021/12/31 00:30 | BUF Sabres v NY Islanders | L | 1-4 |
| NHL | 2021/12/30 00:00 | NJ Devils v BUF Sabres | L | 4-3 |
| NHL | 2021/12/18 00:00 | BUF Sabres v PIT Penguins | L | 2-3 |
| NHL | 2021/12/17 01:00 | BUF Sabres v MIN Wild | W | 3-2 |
| NHL | 2021/12/15 01:00 | BUF Sabres v WIN Jets | W | 4-2 |
| NHL | 2021/12/12 00:00 | WAS Capitals v BUF Sabres | L | 3-2 |
| NHL | 2021/12/11 00:00 | NY Rangers v BUF Sabres | L | 2-1 |
| NHL | 2021/12/08 00:30 | ANA Ducks v BUF Sabres | L | 2-0 |
Away History
| NHL | 2021/12/17 00:30 | BOS Bruins v NY Islanders | L | 1-3 |
| NHL | 2021/12/15 00:00 | VGS Golden Knights v BOS Bruins | L | 4-1 |
| NHL | 2021/12/12 03:00 | BOS Bruins v CAL Flames | W | 4-2 |
| NHL | 2021/12/10 02:00 | BOS Bruins v EDM Oilers | W | 3-2 |
| NHL | 2021/12/09 02:00 | BOS Bruins v VAN Canucks | L | 1-2 |
| NHL | 2021/12/05 00:00 | TB Lightning v BOS Bruins | L | 3-2 |
| NHL | 2021/12/03 01:00 | BOS Bruins v NAS Predators | W | 2-0 |
| NHL | 2021/12/01 00:00 | DET Red Wings v BOS Bruins | L | 2-1 |