TOR Maple Leafs 3-1 OTT Senators 2021-10-04 23:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Sheldon Keefe
Head to Head
| NHL Pre-Season | 2021/09/29 23:00 | TOR Maple Leafs v OTT Senators | W | 4-0 |
| NHL | 2021/05/13 00:00 | TOR Maple Leafs v OTT Senators | L | 3-4 |
| NHL | 2021/04/10 23:00 | OTT Senators v TOR Maple Leafs | W | 5-6 |
| NHL | 2021/03/25 23:00 | TOR Maple Leafs v OTT Senators | W | 3-2 |
| NHL | 2021/03/14 23:00 | TOR Maple Leafs v OTT Senators | L | 3-4 |
| NHL | 2021/02/19 00:00 | OTT Senators v TOR Maple Leafs | W | 3-7 |
| NHL | 2021/02/18 00:00 | OTT Senators v TOR Maple Leafs | W | 1-2 |
| NHL | 2021/02/16 00:00 | OTT Senators v TOR Maple Leafs | L | 6-5 |
Home History
| NHL Pre-Season | 2021/09/29 23:00 | TOR Maple Leafs v OTT Senators | W | 4-0 |
| NHL Pre-Season | 2021/09/27 23:00 | TOR Maple Leafs v MON Canadiens | L | 2-5 |
| NHL Pre-Season | 2021/09/25 23:00 | MON Canadiens v TOR Maple Leafs | W | 1-4 |
| NHL | 2021/05/31 23:00 | MON Canadiens v TOR Maple Leafs | L | 3-1 |
| NHL | 2021/05/29 23:30 | TOR Maple Leafs v MON Canadiens | L | 2-3 |
| NHL | 2021/05/27 23:00 | MON Canadiens v TOR Maple Leafs | L | 4-3 |
| NHL | 2021/05/25 23:30 | TOR Maple Leafs v MON Canadiens | W | 4-0 |
| NHL | 2021/05/24 23:00 | TOR Maple Leafs v MON Canadiens | W | 2-1 |
Away History
| NHL Pre-Season | 2021/10/02 23:00 | OTT Senators v MON Canadiens | L | 1-2 |
| NHL Pre-Season | 2021/10/01 23:00 | MON Canadiens v OTT Senators | W | 2-7 |
| NHL Pre-Season | 2021/09/29 23:00 | TOR Maple Leafs v OTT Senators | L | 4-0 |
| NHL Pre-Season | 2021/09/27 00:00 | OTT Senators v WIN Jets | W | 3-2 |
| NHL | 2021/05/13 00:00 | TOR Maple Leafs v OTT Senators | W | 3-4 |
| NHL | 2021/05/10 00:00 | OTT Senators v CAL Flames | L | 1-6 |
| NHL | 2021/05/08 23:00 | OTT Senators v WIN Jets | W | 4-2 |
| NHL | 2021/05/05 23:00 | MON Canadiens v OTT Senators | W | 1-5 |