[6] BUF Sabres 2-3 DET Red Wings [4] 2021-11-28 00:00
Stadium: Little Caesars Arena
Home Manager: Jeff Blashill Away Manager: Don Granato
Head to Head
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL Pre-Season | 2021/10/09 19:00 | DET Red Wings v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2021/09/30 23:30 | BUF Sabres v DET Red Wings | L | 2-6 |
| NHL | 2020/02/12 00:00 | DET Red Wings v BUF Sabres | W | 2-3 |
| NHL | 2020/02/07 00:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2020/01/12 22:00 | BUF Sabres v DET Red Wings | W | 5-1 |
| NHL | 2019/10/25 23:30 | BUF Sabres v DET Red Wings | W | 2-0 |
| NHL | 2019/04/06 23:00 | BUF Sabres v DET Red Wings | W | 7-1 |
Home History
| NHL | 2021/11/27 00:00 | MON Canadiens v BUF Sabres | W | 1-4 |
| NHL | 2021/11/25 00:00 | BOS Bruins v BUF Sabres | L | 5-1 |
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
Away History
| NHL | 2021/11/25 00:30 | STL Blues v DET Red Wings | W | 2-4 |
| NHL | 2021/11/21 01:00 | DET Red Wings v ARZ Coyotes | L | 1-2 |
| NHL | 2021/11/19 03:00 | DET Red Wings v VGS Golden Knights | L | 2-5 |
| NHL | 2021/11/17 01:30 | DET Red Wings v DAL Stars | L | 2-5 |
| NHL | 2021/11/16 00:00 | DET Red Wings v CLB Blue Jackets | L | 3-5 |
| NHL | 2021/11/14 00:00 | MON Canadiens v DET Red Wings | W | 2-3 |
| NHL | 2021/11/12 00:30 | WAS Capitals v DET Red Wings | L | 2-0 |
| NHL | 2021/11/10 00:30 | EDM Oilers v DET Red Wings | W | 2-4 |