[2] TOR Maple Leafs 5-4 BUF Sabres [5] 2021-11-14 00:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Sheldon Keefe
Head to Head
| NHL | 2020/02/17 00:00 | TOR Maple Leafs v BUF Sabres | L | 2-5 |
| NHL | 2019/12/18 00:00 | BUF Sabres v TOR Maple Leafs | W | 3-5 |
| NHL | 2019/12/01 00:00 | BUF Sabres v TOR Maple Leafs | W | 1-2 |
| NHL | 2019/11/29 21:00 | TOR Maple Leafs v BUF Sabres | L | 4-6 |
| NHL Pre-Season | 2019/09/21 23:00 | TOR Maple Leafs v BUF Sabres | L | 3-5 |
| NHL Pre-Season | 2019/09/20 23:00 | BUF Sabres v TOR Maple Leafs | W | 0-3 |
| NHL | 2019/03/20 23:00 | TOR Maple Leafs v BUF Sabres | W | 4-2 |
| NHL | 2019/03/03 00:00 | BUF Sabres v TOR Maple Leafs | W | 2-5 |
Home History
| NHL | 2021/11/13 00:00 | CAL Flames v TOR Maple Leafs | W | 1-2 |
| NHL | 2021/11/11 00:30 | TOR Maple Leafs v PHI Flyers | W | 3-0 |
| NHL | 2021/11/09 00:30 | LA Kings v TOR Maple Leafs | L | 5-1 |
| NHL | 2021/11/06 23:00 | BOS Bruins v TOR Maple Leafs | W | 2-5 |
| NHL | 2021/11/04 23:00 | TB Lightning v TOR Maple Leafs | W | 1-2 |
| NHL | 2021/11/02 23:00 | VGS Golden Knights v TOR Maple Leafs | W | 0-4 |
| NHL | 2021/10/30 23:00 | DET Red Wings v TOR Maple Leafs | W | 4-5 |
| NHL | 2021/10/27 23:30 | TOR Maple Leafs v CHI Blackhawks | W | 3-2 |
Away History
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |
| NHL | 2021/11/05 02:00 | BUF Sabres v SEA Kraken | L | 2-5 |
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | L | 3-5 |
| NHL | 2021/10/31 20:00 | BUF Sabres v LA Kings | L | 2-3 |
| NHL | 2021/10/29 02:00 | BUF Sabres v ANA Ducks | W | 4-3 |
| NHL | 2021/10/25 23:00 | TB Lightning v BUF Sabres | W | 1-5 |