Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Mike Minter
| NCAAF | 2021/10/30 17:00 | Campbell v Charleston Southern | L | 14-27 |
| NCAAF | 2021/10/23 20:00 | Kennesaw State v Campbell | L | 30-7 |
| NCAAF | 2021/10/16 17:00 | Monmouth v Campbell | L | 34-17 |
| NCAAF | 2021/10/09 22:00 | Campbell v Gardner Webb | W | 42-28 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | W | 48-31 |
| NCAAF | 2021/09/18 22:00 | Presbyterian v Campbell | W | 0-72 |
| NCAAF | 2021/09/11 22:00 | Elon v Campbell | L | 24-23 |
| NCAAF | 2021/09/04 22:00 | Campbell v Liberty | L | 7-48 |
| NCAAF | 2021/10/30 18:00 | Elon v James Madison | W | 21-45 |
| NCAAF | 2021/10/23 19:00 | James Madison v Delaware | W | 22-10 |
| NCAAF | 2021/10/16 18:00 | James Madison v Richmond | W | 19-3 |
| NCAAF | 2021/10/09 18:00 | Villanova v James Madison | L | 28-27 |
| NCAAF | 2021/10/02 19:30 | James Madison v New Hampshire | W | 23-21 |
| NCAAF | 2021/09/19 00:00 | James Madison v Weber State | W | 37-24 |
| NCAAF | 2021/09/11 20:00 | Maine v James Madison | W | 7-55 |
| NCAAF | 2021/09/04 22:00 | Morehead State v James Madison | W | 10-68 |