[58] North Carolina 34-44 Notre Dame [20] 2021-10-30 23:30
Stadium: Notre Dame Stadium Round: 1
Home Manager: Brian Kelly Away Manager: Mack Brown
Head to Head
| NCAAF | 2020/11/27 20:30 | Notre Dame v North Carolina | L | 31-17 |
| NCAAF | 2017/10/07 19:30 | Notre Dame v North Carolina | L | 33-10 |
| NCAAF | 2014/10/11 19:30 | Notre Dame v North Carolina | L | 50-43 |
| NCAAF | 2008/10/11 12:00 | North Carolina v Notre Dame | W | 29-24 |
| NCAAF | 2006/11/04 12:00 | Notre Dame v North Carolina | L | 45-26 |
Home History
| NCAAF | 2021/10/16 19:30 | Miami Florida v North Carolina | W | 42-45 |
| NCAAF | 2021/10/09 19:30 | Florida State v North Carolina | L | 35-25 |
| NCAAF | 2021/10/02 16:00 | Duke v North Carolina | W | 7-38 |
| NCAAF | 2021/09/25 23:30 | North Carolina v Georgia Tech | L | 22-45 |
| NCAAF | 2021/09/18 23:30 | Virginia v North Carolina | W | 39-59 |
| NCAAF | 2021/09/11 23:30 | Georgia State v North Carolina | W | 17-59 |
| NCAAF | 2021/09/03 22:00 | North Carolina v Virginia Tech | L | 10-17 |
| NCAAF | 2021/01/03 01:00 | North Carolina v Texas A&M | L | 27-41 |
Away History
| NCAAF | 2021/10/23 23:30 | USC v Notre Dame | W | 16-31 |
| NCAAF | 2021/10/09 23:30 | Notre Dame v Virginia Tech | W | 32-29 |
| NCAAF | 2021/10/02 18:30 | Cincinnati v Notre Dame | L | 24-13 |
| NCAAF | 2021/09/25 16:00 | Notre Dame v Wisconsin | W | 41-13 |
| NCAAF | 2021/09/18 18:30 | Purdue v Notre Dame | W | 13-27 |
| NCAAF | 2021/09/11 18:30 | Toledo v Notre Dame | W | 29-32 |
| NCAAF | 2021/09/05 23:30 | Notre Dame v Florida State | W | 41-38 |
| NCAAF | 2021/01/01 21:00 | Notre Dame v Alabama | L | 14-31 |