Stadium: Braly Municipal Stadium Round: 1
Home Manager: Chris Willis Away Manager: Autry Denson
| NCAAF | 2021/10/16 22:00 | Hampton v Charleston Southern | W | 5-35 |
| NCAAF | 2021/10/09 19:00 | Charleston Southern v Robert Morris | L | 24-31 |
| NCAAF | 2021/09/25 22:00 | Charleston Southern v East Carolina | L | 28-31 |
| NCAAF | 2021/09/18 22:00 | Monmouth v Charleston Southern | L | 41-14 |
| NCAAF | 2021/09/11 18:00 | Charleston Southern v The Citadel | W | 38-21 |
| NCAAF | 2021/04/17 16:00 | Gardner Webb v Charleston Southern | W | 7-20 |
| NCAAF | 2021/04/10 16:00 | Robert Morris v Charleston Southern | W | 14-27 |
| NCAAF | 2021/03/27 17:00 | Charleston Southern v Monmouth | L | 17-35 |
| NCAAF | 2021/10/16 23:00 | Robert Morris v North Alabama | W | 31-42 |
| NCAAF | 2021/10/09 17:00 | North Alabama v North Carolina A&T | L | 34-38 |
| NCAAF | 2021/10/02 23:00 | Campbell v North Alabama | L | 48-31 |
| NCAAF | 2021/09/25 20:00 | North Alabama v Nicholls State | L | 14-31 |
| NCAAF | 2021/09/18 23:00 | North Alabama v Jacksonville State | L | 24-27 |
| NCAAF | 2021/09/11 23:00 | Tennessee Chattanooga v North Alabama | L | 20-0 |
| NCAAF | 2021/09/04 23:00 | SE Louisiana v North Alabama | L | 49-28 |
| NCAAF | 2020/11/21 20:00 | North Alabama v BYU | L | 14-66 |