[2] SF 49ers 41-33 Detroit Lions [2] 2021-09-12 17:00
Stadium: Ford Field
Home Manager: Dan Campbell Away Manager: Kyle Shanahan
Head to Head
| NFL | 2018/09/16 20:05 | Detroit Lions v SF 49ers | W | 27-30 |
| NFL | 2015/12/27 18:00 | Detroit Lions v SF 49ers | L | 32-17 |
Home History
| NFLi eelhooaeg | 2021/08/29 20:00 | LV Raiders v SF 49ers | W | 10-34 |
| NFLi eelhooaeg | 2021/08/22 23:30 | SF 49ers v LA Chargers | W | 15-10 |
| NFLi eelhooaeg | 2021/08/15 00:30 | KC Chiefs v SF 49ers | L | 19-16 |
| NFL | 2021/01/03 21:25 | SEA Seahawks v SF 49ers | L | 26-23 |
| NFL | 2020/12/26 21:30 | SF 49ers v ARZ Cardinals | W | 20-12 |
| NFL | 2020/12/20 18:00 | SF 49ers v Dallas Cowboys | L | 33-41 |
| NFL | 2020/12/13 21:25 | WAS Commanders v SF 49ers | L | 23-15 |
| NFL | 2020/12/08 01:15 | Buffalo Bills v SF 49ers | L | 34-24 |
Away History
| NFLi eelhooaeg | 2021/08/27 23:00 | IND Colts v Detroit Lions | L | 27-17 |
| NFLi eelhooaeg | 2021/08/21 23:30 | Detroit Lions v PIT Steelers | L | 20-26 |
| NFLi eelhooaeg | 2021/08/13 23:00 | Buffalo Bills v Detroit Lions | L | 16-15 |
| NFL | 2021/01/03 18:00 | MIN Vikings v Detroit Lions | L | 37-35 |
| NFL | 2020/12/26 18:00 | TB Buccaneers v Detroit Lions | L | 47-7 |
| NFL | 2020/12/20 18:00 | Detroit Lions v TEN Titans | L | 25-46 |
| NFL | 2020/12/13 21:25 | GB Packers v Detroit Lions | L | 31-24 |
| NFL | 2020/12/06 18:00 | Detroit Lions v Chicago Bears | W | 34-30 |