Stadium: Toyota Stadium Round: 1
| NCAAF | 2021/05/08 18:30 | James Madison v Sam Houston State | W | 35-38 |
| NCAAF | 2021/05/02 19:00 | North Dakota State v Sam Houston State | W | 20-24 |
| NCAAF | 2021/04/24 16:00 | Monmouth v Sam Houston State | W | 15-21 |
| NCAAF | 2021/04/17 16:00 | Sam Houston State v Incarnate Word | W | 42-14 |
| NCAAF | 2021/04/10 21:00 | McNeese State v Sam Houston State | W | 13-27 |
| NCAAF | 2021/04/01 23:00 | Sam Houston State v Northwestern State | W | 24-16 |
| NCAAF | 2021/03/20 23:00 | Sam Houston State v Lamar | W | 62-7 |
| NCAAF | 2021/03/13 18:00 | Nicholls State v Sam Houston State | W | 17-71 |
| NCAAF | 2021/05/08 16:00 | Delaware v South Dakota State | W | 3-33 |
| NCAAF | 2021/05/03 01:00 | SO Illinois v South Dakota State | W | 26-31 |
| NCAAF | 2021/04/24 19:00 | Holy Cross v South Dakota State | W | 3-31 |
| NCAAF | 2021/04/17 19:30 | South Dakota State v North Dakota State | W | 27-17 |
| NCAAF | 2021/03/20 17:00 | South Dakota State v SO Illinois | W | 44-3 |
| NCAAF | 2021/03/13 20:00 | Youngstown State v South Dakota State | W | 17-19 |
| NCAAF | 2021/03/06 20:00 | Western Illinois v South Dakota State | W | 10-45 |
| NCAAF | 2021/02/27 18:00 | South Dakota State v North Dakota | L | 17-28 |