Home History
| NCAAF | 2000/10/28 12:00 | Houston v Southern Mississippi | W | 3-6 |
| NCAAF | 2000/10/14 12:00 | Tulane v Southern Mississippi | W | 24-56 |
| NCAAF | 2000/10/07 12:00 | Southern Mississippi v South Florida | W | 41-7 |
| NCAAF | 2000/09/30 12:00 | Southern Mississippi v Memphis | W | 24-3 |
| NCAAF | 2000/09/23 12:00 | Oklahoma State v Southern Mississippi | W | 6-28 |
| NCAAF | 2000/09/16 12:00 | Alabama v Southern Mississippi | W | 0-21 |
| NCAAF | 2000/09/02 12:00 | Tennessee v Southern Mississippi | L | 19-16 |
Away History
| NCAAF | 2000/10/28 12:00 | Louisville v Tulane | W | 35-32 |
| NCAAF | 2000/10/19 12:00 | Louisville v East Carolina | L | 25-28 |
| NCAAF | 2000/10/14 12:00 | Louisville v Cincinnati | W | 38-24 |
| NCAAF | 2000/10/07 12:00 | UAB v Louisville | W | 17-38 |
| NCAAF | 2000/09/30 12:00 | Louisville v Connecticut | W | 41-22 |
| NCAAF | 2000/09/23 12:00 | Florida State v Louisville | L | 31-0 |
| NCAAF | 2000/09/09 12:00 | Louisville v Grambling State | W | 52-0 |
| NCAAF | 2000/09/02 12:00 | Louisville v Kentucky | W | 40-34 |